MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.
Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs).However, how WDR62 is regulated and hence controls neurogenesis and brain size remains elusive.Here, we demonstrate that mitogen-activated protein kinase kinase k